{"id":1421,"date":"2024-10-20T07:25:51","date_gmt":"2024-10-20T07:25:51","guid":{"rendered":"https:\/\/ibdcentrebc.ca\/lunkenlab\/?page_id=1421"},"modified":"2026-05-26T00:00:37","modified_gmt":"2026-05-26T00:00:37","slug":"optimist-study","status":"publish","type":"page","link":"https:\/\/ibdcentrebc.ca\/lunkenlab\/optimist-study\/","title":{"rendered":"OPTIMIST Study"},"content":{"rendered":"\n<div class=\"wp-block-cover alignfull is-light\" style=\"margin-top:-15px;min-height:474px;aspect-ratio:unset;\"><img loading=\"lazy\" decoding=\"async\" width=\"1800\" height=\"1200\" class=\"wp-block-cover__image-background wp-image-1305\" alt=\"\" src=\"https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-content\/uploads\/2024\/10\/Participate-Study-Cards.png\" style=\"object-position:50% 38%\" data-object-fit=\"cover\" data-object-position=\"50% 38%\" srcset=\"https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-content\/uploads\/2024\/10\/Participate-Study-Cards.png 1800w, https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-content\/uploads\/2024\/10\/Participate-Study-Cards-300x200.png 300w, https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-content\/uploads\/2024\/10\/Participate-Study-Cards-1024x683.png 1024w, https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-content\/uploads\/2024\/10\/Participate-Study-Cards-768x512.png 768w, https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-content\/uploads\/2024\/10\/Participate-Study-Cards-1536x1024.png 1536w\" sizes=\"auto, (max-width: 1800px) 100vw, 1800px\" \/><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim\" style=\"background-color:#cacad3\"><\/span><div class=\"wp-block-cover__inner-container has-global-padding is-layout-constrained wp-block-cover-is-layout-constrained\">\n<h1 class=\"wp-block-heading has-text-align-center alignwide has-white-color has-text-color has-link-color has-system-font-font-family wp-elements-3ec85dc1effb7d6f2161e1c08654c319\" style=\"padding-top:0;padding-bottom:0;font-size:60px;font-style:normal;font-weight:500\">OPTIMIST Study<\/h1>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group alignwide has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--large);padding-bottom:var(--wp--preset--spacing--large)\">\n<h2 class=\"wp-block-heading\">Purpose of Optimist study<\/h2>\n\n\n\n<p class=\"has-text-primary-color has-text-color has-link-color has-system-font-font-family has-large-font-size wp-elements-d6662344bba416fe36e4ab826176532e wp-block-paragraph\" style=\"font-style:normal;font-weight:300\">The goal of this pilot observational study is to determine if specific microbiome signatures can predict therapeutic responses in adult patients with Crohn&#8217;s disease (CD), a form of inflammatory bowel disease (IBD), living in British Columbia, Canada.&nbsp;<\/p>\n\n\n\n<p class=\"has-text-primary-color has-text-color has-link-color has-system-font-font-family has-large-font-size wp-elements-fdd9755ed28bc5854db7eac37d578377 wp-block-paragraph\" style=\"font-style:normal;font-weight:300\"><strong>The main questions this study seeks to answer are:<\/strong><\/p>\n\n\n\n<ul style=\"font-style:normal;font-weight:300\" class=\"wp-block-list has-text-primary-color has-text-color has-link-color has-system-font-font-family has-large-font-size wp-elements-589c7f80d317d29d90a42506cf63ce3d\">\n<li>How do microbiome profiles differ between active and quiescent CD and non-IBD controls?<\/li>\n\n\n\n<li>Can microbiome signatures across different sample types (fecal, intestinal washings, and intestinal epithelial biopsies) predict response to therapy in CD?<\/li>\n<\/ul>\n\n\n\n<p class=\"has-text-primary-color has-text-color has-link-color has-system-font-font-family has-large-font-size wp-elements-eb50f8f8e7be030cb9d75df2d89ab498 wp-block-paragraph\" style=\"font-style:normal;font-weight:300\">Researchers will compare microbiome signatures in patients with active and inactive CD as well as non-IBD controls to see if there are any microbial signatures that predict response to therapy.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-tertiary-background-color has-background has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"padding-top:var(--wp--preset--spacing--large);padding-bottom:var(--wp--preset--spacing--large)\">\n<h2 class=\"wp-block-heading\">What is involved<\/h2>\n\n\n\n<p class=\"has-text-primary-color has-text-color has-link-color has-system-font-font-family has-large-font-size wp-elements-dd32aa3d99164b77014cc6a621f15267 wp-block-paragraph\" style=\"font-style:normal;font-weight:300\"><strong>Control and IBD participants in Phase 1 will:<\/strong><\/p>\n\n\n\n<ul style=\"font-style:normal;font-weight:300\" class=\"wp-block-list has-text-primary-color has-text-color has-link-color has-system-font-font-family has-large-font-size wp-elements-bfd12bda8d93afd0775197ee5aa22116\">\n<li>Provide stool samples both before the colonoscopy and two weeks after (using an at-home collection kit provided by the research team).<\/li>\n\n\n\n<li>Agree to have several samples collected during the colonoscopy for research purposes (blood, biopsies, intestinal wash).<\/li>\n\n\n\n<li>Complete an online questionnaire about their gastrointestinal symptoms.<\/li>\n\n\n\n<li>Record their diet using a provided food diary template for three days prior to the second stool collection.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-text-primary-color has-text-color has-link-color has-system-font-font-family has-large-font-size wp-elements-d724bdd6f56ac0f1bc18d771743a225a wp-block-paragraph\" style=\"font-style:normal;font-weight:300\"><strong>IBD patients enrolled in Phase 2 will:<\/strong><\/p>\n\n\n\n<ul style=\"font-style:normal;font-weight:300\" class=\"wp-block-list has-text-primary-color has-text-color has-link-color has-system-font-font-family has-large-font-size wp-elements-43ea5183ed03933dd27fc1bffeddf723\">\n<li>Provide stool samples at 4, 8, and 12 months after the initial colonoscopy.<\/li>\n\n\n\n<li>Record their diet using the provided food diary template for three days before each stool collection.<\/li>\n\n\n\n<li>Answer questions related to gastrointestinal symptoms at 4, 8, and 12 months post-colonoscopy.<\/li>\n\n\n\n<li>If another colonoscopy is scheduled as part of care, agree to have several samples collected during the procedure.<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignwide has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-bottom:0;padding-top:var(--wp--preset--spacing--large);padding-bottom:var(--wp--preset--spacing--large)\">\n<h2 class=\"wp-block-heading\">Learn more<\/h2>\n\n\n\n<ul style=\"font-style:normal;font-weight:300\" class=\"wp-block-list has-text-primary-color has-text-color has-link-color has-system-font-font-family has-large-font-size wp-elements-8f0f2a7d61327976ba3a84a620a50df8\">\n<li style=\"text-transform:capitalize\">Visit <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT06453720?locStr=Vancouver,%20BC,%20Canada&amp;country=Canada&amp;state=British%20Columbia&amp;city=Vancouver&amp;cond=Crohn%27s%20Disease&amp;aggFilters=status:rec&amp;rank=9\" target=\"_blank\" rel=\"noopener\" title=\"\">ClinicalTrials.gov<\/a> For More Information<\/li>\n\n\n\n<li>To inquire about participation, email <a href=\"mailto:studies@ibdcentrebc.ca\">studies@ibdcentrebc.ca<\/a><\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull has-tertiary-background-color has-background has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"margin-bottom:0;padding-top:var(--wp--preset--spacing--large);padding-bottom:var(--wp--preset--spacing--large)\">\n<h2 class=\"wp-block-heading\"><strong>Interested in helping advance gut health, microbiome, and nutrition research? <\/strong><\/h2>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized wp-elements-962ba3563d37019af311af1884806331\" style=\"font-style:normal;font-weight:300\"><img loading=\"lazy\" decoding=\"async\" width=\"907\" height=\"600\" src=\"https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-content\/uploads\/2026\/05\/Donate-7-edited.png\" alt=\"\" class=\"wp-image-1919\" style=\"aspect-ratio:1.499243533430942;width:252px;height:auto\" srcset=\"https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-content\/uploads\/2026\/05\/Donate-7-edited.png 907w, https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-content\/uploads\/2026\/05\/Donate-7-edited-300x198.png 300w, https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-content\/uploads\/2026\/05\/Donate-7-edited-768x508.png 768w\" sizes=\"auto, (max-width: 907px) 100vw, 907px\" \/><\/figure>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">Your contribution helps fund gut health, microbiome, and nutrition studies, support participant recruitment, laboratory analyses, and drive the development of innovative therapeutic approaches for people with various gut conditions. Every contribution makes a meaningful impact.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-center is-layout-flex wp-container-core-buttons-is-layout-4927ffd3 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/donate.give.ubc.ca\/page\/68038\/donate\/1?transaction.dirgift=Dr.%20Genelle%20Lunken%27s%20Lab%20Donations%20Supporting%20Gut,%20Nutrition%20and%20Microbiome%20Research%20Fund%20G4588\">Support Our Research<\/a><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Purpose of Optimist study The goal of this pilot observational study is to determine if specific microbiome signatures can predict therapeutic responses in adult patients [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-1421","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-json\/wp\/v2\/pages\/1421","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-json\/wp\/v2\/comments?post=1421"}],"version-history":[{"count":23,"href":"https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-json\/wp\/v2\/pages\/1421\/revisions"}],"predecessor-version":[{"id":1924,"href":"https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-json\/wp\/v2\/pages\/1421\/revisions\/1924"}],"wp:attachment":[{"href":"https:\/\/ibdcentrebc.ca\/lunkenlab\/wp-json\/wp\/v2\/media?parent=1421"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}